نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
2 گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد شهرکرد، شهرکرد، ایران
3 گروه پاتولوژی دامپزشکی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد شهرکرد، شهرکرد، ایران
4 دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد شهرکرد، شهرکرد، ایران
کلیدواژهها
موضوعات
عنوان مقاله English
نویسندگان English
Purpose of Review: Tendinopathy, also called tendinitis, is a common issue in musculoskeletal consultations. Tendon healing is inferior to normal due to low metabolic rate and poor vascularity. R. damascena has anti-inflammatory, antioxidant, and healing effects. This study aims to investigate R. damascene's effects on Achilles tendon injury using histopathology and biomechanical evaluations.
Materials/Methods: Wistar rats were divided into seven groups, including a control group and three groups with tendinitis, that were given different doses of Hydroalcoholic Extract of R. damascene (HERD) (250, 500, 1000 mg/kg) intraperitoneally. Dexamethasone and Vitamin E were used in the reference groups. The Achilles tendon was injured, and the extract was administered for 20 days. Histopathological assessment and antioxidant activity were determined by serum malondialdehyde levels and ferric-reducing antioxidant power assays on days 10 and 20.
Results: Different dosages of HERD, particularly 1000 mg, improved inflammatory intensity, angiogenesis, fibroplasia, and complete tendon regeneration on the 10th and 20th days after the injury, while also reducing unsaturated fatty acid peroxidation and increasing the whole serum's antioxidant capacity on the 20th day.
Conclusions: After a thorough review, it can be concluded that HERD is an effective anti-inflammatory agent and analgesic for preventing and treating tendinitis. Furthermore, it has been deemed safe and well-tolerated, making it a promising option for those seeking relief from the symptoms of tendinitis.
کلیدواژهها English
