تعیین تأثیر داروی پنتوکسی فیلین بر روند بهبود بافت در بیماران دچار قطع تروماتیک نوک انگشتان:یک کار آزمایی بالینی تصادفی

نوع مقاله : مقاله اروجینال

نویسندگان

1 گروه ارتوپدی، واحد توسعه تحقیقات بالینی بیمارستان شهید مدنی، دانشکده پزشکی، دانشگاه علوم پزشکی البرز، کرج، ایران

2 کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی البرز، کرج، ایران

چکیده
چکیده:
مقدمه: هدف از این تحقیق، بررسی تأثیر داروی پنتوکسی فیلین بر روند بهبود زخم‌های ناشی از قطع تروماتیک نوک انگشتان دست در بیماران علی‌الخصوص بیمارانی که به تسریع درمان و نتایج بهتر نیاز دارند.
مواد و روش‌ها: این مطالعه به‌صورت کارآزمایی بالینی تصادفی بر روی ۵۲ بیمار انجام شد که به ‌دلیل قطع انگشتان ناشی از تروما به بیمارستان مراجعه کرده بودند. بیماران به دو گروه مداخله (دریافت‌کننده پنتوکسی فیلین) و گروه کنترل (دریافت‌کننده دارونما) تقسیم شدند. داروی پنتوکسی فیلین در گروه مداخله به میزان ۱۲۰۰ میلی‌گرم در روز به مدت ۲۱ روز تجویز شد. ارزیابی‌ها در سه زمان (روز هفتم، چهاردهم و بیست و یکم) از نظر وضعیت زخم و پیش‌آگهی درمان انجام شد.
نتایج و بحث: نتایج نشان داد که در روز هفتم، درصد کمتری از بیماران گروه مداخله دچار نکروز مرکزی و حاشیه‌ای بودند. همچنین در روزهای چهاردهم و بیست و یکم، بهبود قابل‌توجهی در وضعیت زخم‌ها در گروه مداخله مشاهده شد و پیش‌آگهی درمان در این گروه به ‌طور معناداری بهتر بود. در روز بیست و یکم، ۹۰٪ از بیماران گروه مداخله به بهبودی کامل رسیدند، درحالی‌که در گروه کنترل این رقم ۷۵٪ بود. همچنین، عوارض جانبی پنتوکسی فیلین در گروه مداخله کم و موقتی بود و هیچ‌کدام از بیماران نیاز به قطع دارو نداشتند.
نتیجه‌گیری: استفاده از پنتوکسی فیلین به‌عنوان درمان مکمل در بیماران مبتلا به قطع انگشت ناشی از تروما، تأثیر مثبت و قابل‌توجهی در تسریع بهبودی زخم‌ها و بهبود پیش‌آگهی درمان دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله English

Traumatic Finger-Tip Amputation and the Effect of Pentoxifylline on Tissue Healing(A Comparative Randomized Clinical Trial)

نویسندگان English

Salman Azarsina 1
Arvin Najafi 1
Saeed Behjati 2
Mohammad Sajjad Mirhoseini 1
armin tajik 2
Amir Mohammad Keshavarz Hassani 2
Hamidreza Balaee Saryazdi 2
Sarah Mohebbi 2
1 Department of Orthopedic Surgery, Clinical Research Development Unit of Shahid Madani Hospital, Alborz University of Medical Sciences, Karaj, Iran.
2 Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
چکیده English

Abstract
Introduction: The aim of this study was to investigate the effect of pentoxifylline on the healing process of wounds resulting from traumatic amputation of the fingertips in patients, especially those who need accelerated treatment and better outcomes.
Materials & Methods: This study was conducted as a randomized clinical trial on 52 patients who had referred to a teaching unit with finger-tip amputation after trauma. The patients were divided into two intervention groups (receiving pentoxifylline) and control group (receiving placebo). Pentoxifylline was prescribed in the intervention group at a dose of 1200 mg per day for 21 days. Evaluations were performed at three times (days 7, 14, and 21) in terms of wound status and treatment results.
Results & Discussion: The results showed that on the seventh day, a lower percentage of patients in the intervention group had central and peripheral necrosis. Also, on the fourteenth and twenty-first days, a significant improvement in the condition of the wounds was observed in the intervention group and the prognosis of treatment in this group was significantly better. On the twenty-first day, 90% of patients in the intervention group achieved complete recovery, while in the control group this figure was 75%. Also, the side effects of pentoxifylline in the intervention group were few and temporary, and none of the patients needed to discontinue the drug.
Conclusion: The use of pentoxifylline as a complementary treatment in patients with traumatic finger amputation has a significant positive effect on accelerating wound healing and improving treatment prognosis.

کلیدواژه‌ها English

Pentoxifylline
Traumatic amputation
Finger injuries
Wound healing
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