نوع مقاله : مقاله اروجینال
نویسندگان
1 گروه ارتوپدی، واحد توسعه تحقیقات بالینی بیمارستان شهید مدنی، دانشکده پزشکی، دانشگاه علوم پزشکی البرز، کرج، ایران
2 کمیته تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی البرز، کرج، ایران
کلیدواژهها
موضوعات
عنوان مقاله English
نویسندگان English
Abstract
Introduction: The aim of this study was to investigate the effect of pentoxifylline on the healing process of wounds resulting from traumatic amputation of the fingertips in patients, especially those who need accelerated treatment and better outcomes.
Materials & Methods: This study was conducted as a randomized clinical trial on 52 patients who had referred to a teaching unit with finger-tip amputation after trauma. The patients were divided into two intervention groups (receiving pentoxifylline) and control group (receiving placebo). Pentoxifylline was prescribed in the intervention group at a dose of 1200 mg per day for 21 days. Evaluations were performed at three times (days 7, 14, and 21) in terms of wound status and treatment results.
Results & Discussion: The results showed that on the seventh day, a lower percentage of patients in the intervention group had central and peripheral necrosis. Also, on the fourteenth and twenty-first days, a significant improvement in the condition of the wounds was observed in the intervention group and the prognosis of treatment in this group was significantly better. On the twenty-first day, 90% of patients in the intervention group achieved complete recovery, while in the control group this figure was 75%. Also, the side effects of pentoxifylline in the intervention group were few and temporary, and none of the patients needed to discontinue the drug.
Conclusion: The use of pentoxifylline as a complementary treatment in patients with traumatic finger amputation has a significant positive effect on accelerating wound healing and improving treatment prognosis.
کلیدواژهها English
