داربست‌های مورد استفاده در مهندسی بافت: مروری بر دستاوردها چالش‌ها(مقاله مروری)

نوع مقاله : مروری

نویسندگان

1 کمیته تحقیقات و فناوری دانشجویی، دانشگاه علوم پزشکی و خدمات بهداشتی درمانی همدان، همدان، ایران

2 ایران، همدان، دانشگاه علوم پزشکی همدان، دانشکده پیراپزشکی، گروه علوم آزمایشگاهی

چکیده
چکیده:
مهندسی بافت، علمی نوین و بین رشته ای است که بررسی روش های مورد استفاده در ترمیم ساختاری و عملکردی بافت های آسیب دیده می‌پردازد. یکی از مهمترین مراحل در مهندسی بافت، تهیه داربستی مناسب با ویژگی‌های سازگار با بافت هدف می‌باشد. در سال‌های اخیر با توجه به گسترش تکنولوژی، داربست‌های متعددی با استفاده از روش‌های گوناگون تهیه شده است که جهت ترمیم بافته‌ای متفاوتی کاربرد دارند. مطالعه حاضر به بررسی پژوهش‌های اخیر در خصوص تهیه داربست‌های مورداستفاده در مهندسی بافته‌ای گوناگون پرداخته است. با توجه به نتایج بررسی‌های انجام شده، داربست‌های متعدد شامل کامپوزیت‌ها، نانوفیبرها، هیدروژل‌ها، پلیمرهای سنتتیک یا نیمه سنتتیک و سرامیک‌ها تهیه و استفاده شده‌اند. برخی داربست‌ها نیز در طی سلول زدایی بافته‌ای طبیعی حاصل‌شده‌اند. همچنین روش‌های متعددی همچون الکتروریسی، الکترواسپاینینگ یا چاپ سه‌بعدی به‌منظور تهیه داربست‌های سنتتیک مورداستفاده قرارگرفته‌اند. بااین‌حال نیاز به بررسی‌های بیشتر in-vivo جهت اطمینان از عملکرد مناسب این داربست‌ها در شرایط درون بدن وجود دارد.

کلیدواژه‌ها

موضوعات

عنوان مقاله English

Scaffolds Applied in Tissue Engineering: A Review on Previous Gains and Challenges(Review Article)

نویسندگان English

Mohammadhossein Shams 1
Azin Atabakhsh 1
Mohammadreza Safari 2
1 Student research committee, Hamedan university of medical sciences and health services, Hamedan, Iran
2 Department of medical laboratory, school of paramedicine, hamedan university of medical sciences and health services, Hamedan, Iran
چکیده English

Abstract

Tissue engineering is a modern and interdisciplinary science that examines the methods used in the structural and functional restoration of damaged tissues. One of the most important steps in tissue engineering is to prepare a suitable scaffold with characteristics compatible with the target tissue. In recent years, many scaffolds have been prepared, to repair different tissues. The present study examines recent research in the preparation of scaffolds in various tissue engineering. Many scaffolds including composites, nanofibers, hydrogels, synthetic or semi-synthetic polymers and ceramics have been prepared and used. Some scaffolds are also obtained during decellularization of natural tissues. Various methods, like electrospinning or 3D printing, have been used to prepare synthetic scaffolds. However, there is a need for more in-vivo studies to ensure the proper functioning of these scaffolds in in-body conditions.

کلیدواژه‌ها English

Tissue engineering
Regenerative medicine
Tissue scaffolds
Composite tissue allograft
1         Razavi Z-S, Soltani M, Mahmoudvand G, Farokhi S, Karimi-Rouzbahani A, Farasati-Far B, et al. Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective. Frontiers in Bioengineering and Biotechnology. 2024;12.
2         Razavi ZS, Farokhi S, Mahmoudvand G, Karimi-Rouzbahani A, Farasati-Far B, Tahmasebi-Ghorabi S, et al. Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights. Frontiers in Cell and Developmental Biology. 2024;12.
3         Kiani M, Abbasi M, Ahmadi M, Salehi B. Organ transplantation in Iran; current state and challenges with a view on ethical consideration. Journal of clinical medicine. 2018;7(3):45.
4         Schulz K-H, Kroencke S. Psychosocial challenges before and after organ transplantation. Transplant Research and Risk Management. 2015:45-58.
5          Jalali Jahromi A, Mirhosseini M, Molla Hoseini H, Nikukar H. A Review on Commonly Used Scaffolds in Tissue Engineering for Bone Tissue Regeneration. The Journal of Shahid Sadoughi University of Medical Sciences. 2020;28(1):2235-54.
6         Liao S, Chan CK, Ramakrishna S. Stem cells and biomimetic materials strategies for tissue engineering. Materials Science and Engineering: C. 2008;28(8):1189-202.
7         Safari M. Free radicals in biological systems. 1, editor. Hamedan University of Medical Sciences and Health Services: Hamedan University of Medical Sciences and Health Services Research Deputy; 2002. 261 p.
8         Chen G, Ushida T, Tateishi T. Scaffold design for tissue engineering. Macromolecular Bioscience. 2002;2(2):67-77.
9         Abd El-Aziz AM, Serag E, Kenawy MY, El-Maghraby A, Kandil SH. Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering. Front Bioeng Biotechnol. 2023;11:1170097.
10      Lynch CR, Kondiah PPD, Choonara YE. Advanced Strategies for Tissue Engineering in Regenerative Medicine: A Biofabrication and Biopolymer Perspective. Molecules. 2021;26(9).
11      Abdollahi F, Saghatchi M, Paryab A, Malek Khachatourian A, Stephens ED, Toprak MS, et al. Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements. Biomater Adv. 2024;159:213828.
12      Mohammad K, Amini. Anisotropy of mechanical properties of polylactic acid scaffolds produced by melt deposition method for bone tissue engineering. New processes in materials engineering. 2021;15(1):67-72.
13      Mohammadi r, shaki, kargozar. Fabrication of nanofibrous hybrid scaffolds from polylactic acid-graphene and gelatin for use in bone tissue engineering. Journal of Polymer Science and Technology. 2019;31(6):563-74.
14      Orafa i, shiva, zamanian, bakshi, nikookar, habib, ghalandari, behafarid. Evaluation of biocompatibility of laponite-coated PLA scaffold on human bone marrow mesenchymal stem cells. Animal Biology Quarterly. 2021;13(4):101-17.
15      Abutalebi p, abbas tabarahangar. The effect of adding zinc oxide on the antibacterial behavior of hydroxyapatite-polylactic-coglycolic acid composite scaffold for bone tissue engineering applications. Biology of microorganisms. 2018;7(25):33-43.
16      Vida h, Mahbube M, Marjan M. Fabrication and evaluation of surface properties and biodegradability of polycaprolactone/keratin nanofibrous scaffold containing carbon nanotubes for use in bone tissue engineering.
17      Sahnazari, Koupaiee. Fabrication and characterization of tissue engineering network scaffold based on polycaprolactone DL/polyethylene glycol diacrylate/hydroxyapatite. Scientific-research quarterly journal of new materials. 2019;10(37):33-46.
18      Sharifi, Karimi, Taban, Shiriyan, Sadegh, Mirzaiee. Comparative study of the effect of chitosan and chitosan along with hyaluronic acid on wound healing in rats. Veterinary clinical sciences of Iran. 2021;15(1):55-68.
19      Ghosoori, Setayeshmehr, Tahrikafrani, Dehghani, Valiani. Characterization of polycaprolactone/extracellular matrix nanofiber composite scaffold for use in tissue engineering. Journal of Isfahan Medical School. 2019;37(521):296-302.
20      Shafiee, Seyedesara, Shavandi, Nikakhtar, Yegane. Investigating the effect of adding nanoclay on the properties of polycaprolactone nanocomposite scaffold containing mesenchymal stem cells derived from adipose tissue for use in soft tissue engineering. Scientific-research journal of advanced materials in engineering. 2022;39(4):45-59.
21      Baaji, Pezeshkimodares, Mohammad, Rajabi. A review in vascular tissue engineering: advances and challenges. Razi Journal of Medical Sciences. 2019;26(5):114-30.
22      Tabesh DH, Gholamichaharesh S, Rezaiee M, houshman DB. Investigating the physicochemical properties of nanoclinoptilolite scaffold, TCP-β, gelatin and its application in periodontal tissue engineering. Journal of Research in Dental Sciences. 2020;17(4).
23      Jirofti, Mohebikalhori, Davoud, Hajizade, Afra, Samimi. Studying the amount of changes in Young's modulus and fracture resistance in polyurethane-based binary polymer composite structures based on stress-strain loading for use in blood vessel tissue engineering. Amirkabir Mechanical Engineering Journal. 2019;52(12):3567-82.
24      Nazadi, Keshvari, Yousefzade. Optimization of polyurethane scaffolds with Taguchi test design for vascular tissue engineering applications. Journal of Polymer Science and Technology. 2020;33(5):419-33.
25      Najme D, Mohsen H, Saeed F, Seyedmohammad M, Habib N. Development of polyurethane nanofibrous scaffold for vaginal tissue engineering. 2021.
26      Zargar, Shaghayegh, Asefnejad, Azade, Azami, Mahmoud, et al. Fabrication and characterization of collagen/silk fibroin nanofibrous scaffolds for corneal tissue engineering. Advanced materials and technologies. 2022.
 
27      Johari, Madahhoseini, Samadikouchaksaraii. Comparison of bioactive behavior of fibroin/titanium dioxide nanoparticles and fibroin/titanium dioxide nanoparticles containing fluorine ion nanocomposite scaffolds for bone tissue engineering. Metallurgical and materials engineering. 2021;32(1):75-84.
28      Tavakol, Moslem, Vasheghanifarhani, Ebrahim, Soleymani, Masoud, et al. Preparation of in situ enzymatically formed hydrogel from chemically modified catira for cartilage tissue engineering. Journal of cellular and molecular research (scientific). 2019;32(3):297-310.
29      Arastouii, Masoud, Doustmohammadi. Fabrication and characterization of porous titanium scaffold coated with ackermanite. New processes in materials engineering. 2017;11(2):87-98.
30      Arwana, reza A, Shojaei S. Application of biodegradable aliphatic polyesters in tissue engineering. Journal of Polymer Science and Technology. 2021;34(4):319-48.
31      Hossein Ged, Ebrahim V, Seyed Mehdi B, Nader M. Investigation of the production of polyhydroxyalkanoates (PHAs) in an activated sludge reactor. 2005.
32      Borhan, Esmailzade. Fabrication of nanostructured apatite scaffolds by freeze casting method for bone tissue engineering. Advanced materials and technologies. 2021;10(2):21-31.
33      Alahgahi, Fatahi, Saeedi, Mortazaviroodmiane, Mirmahmud. Studying the biological, compositional and surface topographic properties of hydroxyapatite/ostrich eggshell granular scaffold for bone tissue engineering. Animal Biology Quarterly. 2021;13(3):27-40.
34      Sina Y, Hosein N, Hosein K. Fabrication of 3D-printed polycaprolactone/hydroxyapatite scaffolds coated with platelet-rich fibrin for bone tissue engineering. Iranian Journal of Veterinary Medicine. 2022;16(4):400-13.
35      Angoorajtaghavi, Rabiee, Jahanshahi, Nasiri. The effect of dicalcium phosphate dihydrate bioceramic nanoparticles on electrospun polycaprolactone nanofibers with the aim of bone tissue engineering. Journal of Ceramic Science and Engineering. 2018;7(3):63-72.
36      Satari, Rafieenia, Mohammad, Khorasani, Salehirazave. Cell behavior study of polycaprolactone/gelatin electrospun scaffold containing hydroxyapatite nanoparticles and vitamin D3. Journal of Isfahan Medical School. 2017;35(425):387-92.
37      Ehterami, Arian, Saraieean, Payam, Etemadihaghighi, Azamai, et al. Fabrication and investigation of properties of barium titanate scaffold with nano hydroxyapatite coating for bone tissue engineering. Modares Mechanical Engineering. 2018;17(12):417-22.
38      Dini, Javadpour, Jafar, Ghafari, Rezaiee. Investigating factors affecting the production of raw calcium phosphate parts by 3D printing method. Journal of Ceramic Science and Engineering. 2020;9(1):71-7.
39      Khavandi, Basaeri, Vahid. Investigating the effect of natural and synthetic hydroxyapatite in 3-component scaffold, HA, carbon nanotube and gelatin. Iranian Ceramic Quarterly. 2018;14(3):27-32.
40      Tohidlou, Shafiee, Seyedesara, Shiralipour. Fabrication and evaluation of electrospun polycaprolactone/aminated carbon nanotube nanocomposite scaffold containing mesenchymal stem cells for use in hard tissue engineering. Advanced materials and technologies. 2020;8(4):19-30.
41      Soltani, Mohammad, Yousefpoor, Mardali, Taherian. Fabrication, characterization and biological evaluation of sodium alginate-fluorohydroxyapatite composite scaffold for use in bone tissue engineering. Composite science and technology. 2019;6(3):481-90.
42      Gharghi M, Gharaviane M, Rafiee M. Investigating the behavior of MG63 cells on electrospun polycaprolactone/carbon quantum dot nanocomposite scaffold containing captopril for bone tissue engineering.
43      Bohloli, Tamjid, Mohammadi, Nikkhah. Study of cytotoxicity, hemocompatibility and antibacterial properties of composite scaffolds based on polycaprolactone containing tetracycline hydrochloride for use in bone tissue engineering. Biotechnology. 2020;11(1):61-9.
44      Najafi, Asadi, Zohri, Saber, Abdolmaleki. Fabrication of nanofiber scaffolds using polycaprolactone containing silymarin to study neural cell tissue engineering. Journal of Ardabil University of Medical Sciences. 2022;22(1):7-17.
45      Geetha S, Rao CR, Vijayan M, Trivedi D. Biosensing and drug delivery by polypyrrole. Analytica Chimica Acta. 2006;568(1-2):119-25.
46      Kheilnezhad B, Safaei Firoozabady A, Aidun A. An overview of polyaniline in tissue engineering. Journal of Tissues and Materials. 2020;3(4):6-22.
47      Edwards SL, Werkmeister JA, Ramshaw JA. Carbon nanotubes in scaffolds for tissue engineering. Expert Review of Medical Devices. 2009;6(5):499-505.
48      Daraieenejad, Shabani, Iman. A review of conductive nanofibrous scaffolds for tissue engineering applications. Journal of Polymer Science and Technology. 2019;32(3):189-210.
49      Arzanipour, Yasaman, Abdolmaleki, Asadi, Zohri, Saber. Synthesis, identification and evaluation of supportive properties and neuroprotective effects of cerium oxide nanoparticles as a candidate in neural tissue engineering. Shafai Khatam Journal of Neuroscience. 2021;9(3):55-63.
50      Seyadesaeede, Sahraee, Kalhor N, Sheykhhasan M. Application of scaffolds in cartilage tissue engineering. Razi Journal of Medical Sciences. 2019;26(8).
51      Mashayekhi, Mirzade, Bagherikholanjani, Shadab. The effect of cross-linking and neutralizing agents on the morphology of electrospun chitosan scaffolds. Journal of Polymer Science and Technology. 2017;29(6):519-29.
52      Ahmadi, Fadavi, Akram, Gahrouiee S, Hasannasab. Evaluation of chitosan scaffold characteristics synthesized by enzymatic method and its efficiency for loading neonatal fibroblast cells. Researches in cell culture and karyotic tissues. 2022;2(4).
53      Aghampouni I, Azade, Sharifzadebaiee, Koshal H, Khiavi A. Design of porous hybrid scaffold based on PEPC modified with chitosan for application in soft tissue engineering: investigation of structural similarities and biomechanical behavior. Practical research in chemistry. 2020;14(1):91-108.
54      Gholami, Asadi, Abdolmaleki, Zohri, Saber. Evaluating the efficiency of selenium nanoparticles in the production of decellularized neural scaffolds and the ability to preserve stem cells cultured on them: a laboratory study. Scientific Journal of Rafsanjan University of Medical Sciences. 2021;20(7):733-46.
55      Abdolmaleki, Ghayour, Zohri, Saber, Asadi, Rasouli, et al. Preparation of decellularized sciatic nerve scaffold and evaluation of its histological characteristics and mechanical properties for use in peripheral nerve repair. Journal of Faculty of Medicine, Tehran University of Medical Sciences. 2019;77(2):115-22.
56      Majidigharenza, Movahedin, Mazaheri. Preparation of biocompatible testicular scaffold for use in tissue engineering. Razi Journal of Medical Sciences. 2020;27(4):37-48.
57      Najafizangir, Asadi, Zohri, Saber. Preparation of biological scaffold derived from sheep bladder and investigation of biocompatibility and mechanical properties of the scaffold. Cell and tissue. 2019;10(3):181-92.
58      Zare, Sona, Ahmadi, Mohammadnia, Niloofarshzade, Mahmoudi, et al. Synthesis, structure and optical characterization of gelatin hydrogel for skin tissue engineering. Medical laser scientific-research quarterly. 2021;17(4):21-9.
59      Matlabitalatape, Sogol, Sharifzadebaii, Heidarykoshal. Investigating the role of methyl cellulose in the structure of heat-sensitive hydrogel as an injectable system for use in soft tissue engineering: fabrication and characterization. Practical research in chemistry. 2020;14(2):27-46.
60      Hasannia, Shahriar, Bahri, Gashtasbi, Dabirmanesh. A review of the applications of fibrin and its derivatives in wound healing and tissue engineering. Biotechnology. 2020;11(3):15-22.
61      Sethi A, Sher M, Akram MR, Karim S, Khiljee S, Sajjad A, et al. Albumin as a drug delivery and diagnostic tool and its market approved products. Acta Pol Pharm. 2013;70(4):597-600.
62      Ragheb, Golzar, Saeedifar, Javadpour, Jafar. Nanocomposite based on albumin protein and a review of its applications in medical engineering. Journal of Ceramic Science and Engineering. 2021;9(4):76-105.
63      Janitermi, Fatahi, Joursaraii, Seyedgholamali. Fabrication of electrospun fibroin scaffold and the effect of its pre-incubation in the culture medium on the survival and adhesion of rat bone marrow mesenchymal cells. Developmental biology. 2021;13(2):19-30.
64      Sadeghzade, Sarvar, Emadi, Labaf, Sheida. Fabrication and evaluation of mechanical and bioactive properties of hardistonite nanostructure scaffold using spacer. Scientific-research journal of advanced materials in engineering. 2022;37(1):55-67.
65      Ahangar At. Investigating the structural and biological properties of nano hydroxyapatite composite scaffold coated with PLGA containing nano copper oxide doped with silver. Nanochemistri and electrochemistry. 2021;1(1):26-36.
66      Roshanzade, Sahebghadamlotfi, Arjmand. Differentiation of rat adipose mesenchymal stem cells into hepatocyte-like cells using 3D gelatin/laminin scaffold. Researches in cell and tissue. 2021;2(2):8-20.
67      Mahmoudi, Haghighi, Mirhaj. Fabrication and evaluation of surface properties and biodegradability of polycaprolactone/keratin nanofibrous scaffold containing carbon nanotubes for use in bone tissue engineering. Scientific-research quarterly journal of new materials. 2020;11(39):15-30.
68      Ganji, Baradaran, Mhya, Sedighian. Application of electrospun nanofibers in tissue engineering: scaffolds with slow release of growth factors. Basparesh scientific quarterly. 2021;11(2):31-41.
69      Janfada, Asefnejad, Azade, Khorasani, Dalirijoupari. Evaluation of the effect of voltage and working distance parameters on the morphology of polycaprolactone-KIT-6 scaffold made by electrospinning method. Iranian Journal of Chemistry and Chemical Engineering. 2020.
70      Avossa J, Herwig G, Toncelli C, Itel F, Rossi RM. Electrospinning based on benign solvents: current definitions, implications and strategies. Green Chemistry. 2022;24(6):2347-75.
71      Raeisdasteh Hokmabad V, Davaran S, Ramazani A, Salehi R. Design and fabrication of porous biodegradable scaffolds: a strategy for tissue engineering. Journal of Biomaterials Science, Polymer Edition. 2017;28(16):1797-825.
72      Bachs-Herrera A, Yousefzade O, del Valle LJ, Puiggali J. Melt Electrospinning of Polymers: Blends, Nanocomposites, Additives and Applications. Applied Sciences. 2021;11(4):1808.
73      Tang Y, Lin Y, Ma W, Wang X. A review on microporous polyvinylidene fluoride membranes fabricated via thermally induced phase separation for MF/UF application. Journal of Membrane Science. 2021;639:119759.
74      Chua CK, Leong KF, An J. Introduction to rapid prototyping of biomaterials. Rapid prototyping of biomaterials: Elsevier; 2020. p. 1-15.
75      Pina S, Ribeiro VP, Marques CF, Maia FR, Silva TH, Reis RL, et al. Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications. Materials (Basel). 2019;12(11).
76      Varma MV, Kandasubramanian B, Ibrahim SM. 3D printed scaffolds for biomedical applications. Materials Chemistry and Physics. 2020;255:123642.