نوع مقاله : مقاله پژوهشی
نویسندگان
1 بخش جراحی و رادیولوژی دامپزشکی، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران
2 گروه علوم بالینی، دانشکده دامپزشکی، دانشگاه شهرکرد، شهرکرد، ایران
3 گروه پاتولوژی، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران
کلیدواژهها
موضوعات
عنوان مقاله English
نویسندگان English
Abstract
Introduction: This study was performed to evaluate the effect of lyophilized human platelet rich plasma powder (LhPRP) and omentum autograft on the bone healing properties in animal model which can further be utilized for different orthopedic or maxillofacial reconstructive surgeries.
Materials & Methods: Bone defects of 10 mm diameter were created in diaphysis of radius of 20 rabbits and then either left undisturbed (control group) or filled with one of the following materials: a piece of autogenous omentum, LhPRP, or concurrent use of LhPRP and omentum. Bone formation, union and remodeling, were evaluated at the 2nd, 4th, 6th and 8th weeks postoperatively by radiography, using bone healing criteria. On 56th postoperative day, the operated limbs were removed and further histopathological evaluations were carried out.
Results & Discussion: The results showed that LhPRP with or without omentum in bone regeneration in 10mm defects was significantly superior to control group (p<0.05).
Conclusion: LhPRP powder, alone or combined with autogenic omentum, provides increased bone regenerative properties in experimental bone defects in animal model after 56 days.
Keywords: Omentum, Lyophilization, Platelets, Bone regeneration, Rabbits.
کلیدواژهها English
