نویسندگان

1 دانشگاه علوم پزشکی مشهد

2 دانشگاه علوم پایه مشهد

چکیده

بافت‎های ارتوپدی مانند استخوان‎ها، غضروف‎ها و تاندون‎ها شامل سلول‎هایی هستند که برای کشت و بازسازی بافت آسیب‎دیده دشوار هستند. تعداد کمی از سلول‎هایی که سلول‎های بنیادی نامیده می‎شوند، توانایی خود نوسازی و تمایز به سلول‎های بافت همبند، شامل استخوان، غضروف، تاندون و لیگامان را دارند. پیشرفت اخیر در تحقیقات سلول‎های بنیادی منجر به تلاشی هیجان‎انگیز برای بکارگیری سلول‎های بنیادی در بازسازی بافت ارتوپدی شده است. در این بررسی خلاصه‎ای از یافته‎های اخیر در مورد استفاده بالینی بالقوه از (Mesenchymal Stem Cells)MSCs در برنامه‎های ارتوپدی به‎عنوان مثال عدم جوش‎خوردگی استخوان، استخوان‎سازی ناقص، نقص در غضروف انسان، استئوآرتریت و آرتریت روماتوئید و درک بهتر از مسائل مربوط به تحقیقات سلول‎های بنیادی و همچنین هدف بالقوه درمانی از این سلول‎ها در عمل جراحی ارتوپدی ارائه شده است.

کلیدواژه‌ها

عنوان مقاله [English]

Review Article Mesenchymal Stem Cells and Orthopaedics (A Current Concept)

نویسندگان [English]

  • amin razi 1
  • Mohammad-Taghi Peivandi 1
  • Ali Birjandinejad 1
  • Ali Parsa 1
  • Sara Amel Farzad 1
  • Maryam Hosseini Hasanabady 2

چکیده [English]

Orthopaedics tissues, such as bone, cartilage, and tendon, involve cells that are difficult to culture and grow in vitro for reconstruction of damaged tissues. A small number of cells called stem cells have the ability to self-renew and differentiate into connective tissue lineages, involving bone, cartilage, tendon and ligaments. Recent development in stem cell research has led to an exciting effort in applying stem cells for orthopaedics tissue regeneration. This review summarizes recent findings regarding the potential clinical use of Mesenchymal Stem Cells (MSCs) in Non:union:s, Osteogenesis imperfect, Human Cartilage defects, Osteoarthritis and Rheumatoid arthritis to provide a better understanding of the issue engineering with stem cell research, as well as the potential therapeutic purpose of these cells in orthopedic surgery.


 

کلیدواژه‌ها [English]

  • Keywords: Mesenchymal stem cells
  • Orthopaedics
  • Clinical trial
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