Nano-Hydroxyapatite: A Driving Force for Bone Tissue Regeneration in Orthopedic Surgery: Challenges and Future(Review Article)

Rahimi, Mohsen ,; Jafarnia, Bahram; Zolfkhani, Kamyar; Pirmohamadi, Hosein; Emamgholi, Asgar

doi:10.22034/ijos.2025.546577.1155

Nano-Hydroxyapatite: A Driving Force for Bone Tissue Regeneration in Orthopedic Surgery: Challenges and Future(Review Article)

Document Type : Review

Authors

Mohsen , Rahimi ¹ ^¶

Bahram Jafarnia ² ^¶

Kamyar Zolfkhani ² ^¶

Hosein Pirmohamadi ³

Asgar Emamgholi ⁴ ^¶

¹ Department of Parasitology and Mycology, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.

² Shahid Shokri Dental Hospital, Tehran, Iran.

³ Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

⁴ Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

https://doi.org/10.22034/ijos.2025.546577.1155

Abstract

Nanotechnology is currently recognized as a technology with vast application potential across multiple fields, particularly in medicine. Nanomaterials and nanostructures, owing to their ultra-microscopic dimensions, high surface area, and unique physicochemical properties, are increasingly employed in orthopedic surgeries. These materials, due to their distinctive features in interacting with living tissues, are considered key components in prostheses and medical devices, and they have led to significant advancements in bone tissue engineering, the design of implantable materials, and diagnostic as well as therapeutic processes. In this study, various databases including ISI Web of Science, PubMed, SID, Scholar, Scopus, and ScienceDirect were utilized. The keywords applied consisted of nanohydroxyapatite, bone defect repair, prosthesis, clinical evaluation, and fracture healing. The use of biocompatible nanomaterials in orthopedic prostheses—particularly due to their ability to stimulate cellular growth, regenerate damaged tissues, and improve cellular microenvironmental properties—has had a profound impact on enhancing orthopedic therapies. These technologies have successfully facilitated bone repair processes. This article has been prepared to provide a deeper understanding of the application of hydroxyapatite at the nanoscale and its potential therapeutic objectives in orthopedic surgeries.

Keywords

Limb prosthesis, Biotechnology, Nano hydroxyapatite collagen, Bone regeneration

Subjects