Iranian Journal of Orthopedic Surgery

Efficacy of Parathyroid Hormone on Diaphysis Delayed-:union: and Non-:union: Fractures of Tibia/Fibula in shahid kamyab hospital in 97-98

Document Type : Original Article

Authors

mohamad taghi peivandi 1
Farshid Bagheri 1
Ali Birjandi nezhad 1
Sara Amel Farzad 2
Lida Jarahi 3
Milad Esmail zade 4
Amin Razi 5
Reza Habibzadeh shojaie 6

1 Associate professor of Department of Orthopaedics, Mashhad University of Medical Sciences, Emdadi Kamyab Hospital, Mashhad, Iran.

2 Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

3 Associate professor of Department of Orthopaedics, Mashhad University of Medical Sciences, Emdadi Kamyab Hospital, Mashhad, Iran

4 Resident of orthopedic surgery of Department of Orthopaedics, Mashhad University of Medical Sciences, Emdadi Kamyab Hospital, Mashhad, Iran.

5 Assistant Professor of Department of Orthopaedics, Mashhad University of Medical Sciences, Emdadi Kamyab Hospital, Mashhad, Iran.

6 Mashhad University of Medical Sciences

https://doi.org/10.22034/ijos.2021.130298
Abstract
Introduction
The use of parathyroid hormone in the management of fracture disorders is poorly documented. Aim of study was evaluation of parathyroid hormone efficacy on :union: of tibia/fibula diaphysis fractures.
Materials and methods:
It was a hospital-based study who conducted on patient with non-:union: or delayed-:union: fracture of tibia/fibula. At Shahid Kamyab hospital, patients with inclusion criteria, entered the study after completing the conscious consent form in both case and control groups. CBC, ESR, Ca, P, Mg, ALK-P, Cr, BUN tests were performed as baseline, then in the case group prescribe oral D-Calcium and monthly injection of parathyroid hormone for 3 months at a daily dose of 8 units and in the control group, prescribe oral D-Calcium and the expected treatment method, and those who had a specific risk factor such as digoxin tablets or kidney failure were excluded from the study. After entering the study and receiving the hormone once the month, patients evaluate with radiographic parameter. 
Results:
Of evaluated cases, mean and standard deviation of age in the intervention group was 16.9 ± 37.7 years and in the control group was 13.8 ± 39.1 years (P = 0.73). In terms of gender in the two groups, 24 cases were male and 6 cases were female (P = 1.0). In addition in clinical findings, fracture type (P = 1.0), fracture shape (P = 0.18), fixation method (P = 0.26), radiographical result (P = 0.06) did not have a statistically significant difference between the two groups.
Conclusion:
We not find any positive effect of this hormon on fracture status, as clinical or para clinical evaluation.

Keywords

Parathyroid Hormone
Delayed :union:
Non-:union:
Diaphysis Fractures
Tibia/Fibula

Subjects

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