Rasoul Rahimzadeh, PhD; Pejman Nazem Zomorrodi, PhD; Mohammad Farzin Tajavanchi
Abstract
Background: Nano could promote strong biological bonding between implants. In this study the effect of cancellous bone scaffold coated with/without Nano-hydroxyapatite in vivo using an animal model of bone healing was studied. Methods: In an experimental study, 18 adult male New Zealand white rabbits ...
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Background: Nano could promote strong biological bonding between implants. In this study the effect of cancellous bone scaffold coated with/without Nano-hydroxyapatite in vivo using an animal model of bone healing was studied. Methods: In an experimental study, 18 adult male New Zealand white rabbits were used dividing into three groups of six rabbits each. A segmental bone defect of 10 mm in length was created in the middle of the right radial shaft under general effective anesthesia in all rabbits. The defects in group I were left as such without filler, in group II the defect were filled up with harvested 10 mm rib bone and in group III the defect were packed with rib bone covered with nano-hydroxyapatite. The operated radiuses were removed on the 60th day and were pathologically and biomechanically evaluated. Results: The radiographs showed a trace of internal callus filled the gap in 60 days in group I, whereas in group II and III internal callus almost was formed on 30 days. Repair defect in group I and II with group III and load bearing of group II, III compared with group I showed no significant difference (p < /em>
Ghader Ghanizadeh; Mohammad Reza Naghii; Giti Torkaman; Mohamood Mofid; Mehdi Hedayati; Peyman Darwishi; Yousef Ebrahimpoor
Abstract
Background: Optimal nutrition plays a role in formation and maintenance of bone. Besides major components of mineralization such as Ca, P and Vitamin D, other nutrients like Boron and Fluoride have also beneficial role. In this study, we are reporting the effect of these elements on metabolic hormones ...
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Background: Optimal nutrition plays a role in formation and maintenance of bone. Besides major components of mineralization such as Ca, P and Vitamin D, other nutrients like Boron and Fluoride have also beneficial role. In this study, we are reporting the effect of these elements on metabolic hormones and biomechanical parameters of bone in rat. Methods: 34 male wistar rats were divided into five groups: Control diet, Fluoride, Fluoride+Boron, Fluoride+ Ca+D, and Fluoride+B+Ca+D. Boron equal to 1.23 mg, Ca and Vit D 210 mg-55 IU and F, 0.7 mg/rat/day was added to their drinking water for 8 weeks. The serum level of the above elements was analyzed. The change in mechanical properties of femur and fifth vertebral body were also tested. Results: The addition of F+B intake revealed significant effects on bone mechanical changes properties and bone metabolic hormones. These findings suggested that combined intake of the above two elements had beneficial effect on bone stinffness and breaking strenght compared with Ca+Vit D supplementation. Conclusion: Dealing with health problems related to the skeletal system in humans, this paper justifies further investigation into the role of Boron and Fluoride in bone mass and strength.
