M Fakor; P Mohammad Hosseini; Arman Shahriayari; E Sabz alipour
Abstract
AbstractIntroduction: This study aimed to investigate the risk factors and the effectiveness of calcium and vitamin D intake in controlling the progression of osteoporosis.Methods: This was a retrospective medical records study of the patients with osteoporosis, assessed from 2014 to 2018 in the bone ...
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AbstractIntroduction: This study aimed to investigate the risk factors and the effectiveness of calcium and vitamin D intake in controlling the progression of osteoporosis.Methods: This was a retrospective medical records study of the patients with osteoporosis, assessed from 2014 to 2018 in the bone density measurement center of Imam Khomeini Hospital in Ahvaz. Patients with a T-score of less than -2.5 and patients with at least two repeat tests in their medical records were included. After collecting patient information, the correlation between osteoporosis and positive or negative history of underlying disease or family history was evaluated. The effectiveness of calcium and vitamin D in controlling the progression of osteoporosis in those patients was also assessed.Results: 16% of patients had a positive family history and 51% of patients had an underlying disease that was not significantly associated with osteoporosis. Decreased bone density in the spine area and femoral neck was significantly lower in people without basal calcium deficiency disease (P = 0.04). Changes in bone density between patients with and without underlying disease receiving calcium-D supplementation were significantly different (P = 0.02) so that in people with underlying disease, the decrease in bone density was significantly higher. There was no significant difference in changes in bone density in the spine and femoral neck between patients with and without the underlying disease who had not received calcium-D supplementation (P = 0.64).Conclusion: Based on the results of the present study, there was no significant correlation between low densitometry measurements and osteoporosis in those with underlying problems like old age, nutritional factors, lifestyle and inactivity, smoking, menopause in women and low testosterone levels in men. It is important to pay attention to other risk factors in this population of patients. Calcium-D supplementation had shown a meaningful efficacy in patients without underlying disease, but this efficacy was not observed in patients with underlying disease.
Ghader Ghanizadeh; Mohammad Reza Naghii; Giti Torkaman; Mohamood Mofid; Mehdi Hedayati; Peyman Darwishi; Yousef Ebrahimpoor
Abstract
Background: Optimal nutrition plays a role in formation and maintenance of bone. Besides major components of mineralization such as Ca, P and Vitamin D, other nutrients like Boron and Fluoride have also beneficial role. In this study, we are reporting the effect of these elements on metabolic hormones ...
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Background: Optimal nutrition plays a role in formation and maintenance of bone. Besides major components of mineralization such as Ca, P and Vitamin D, other nutrients like Boron and Fluoride have also beneficial role. In this study, we are reporting the effect of these elements on metabolic hormones and biomechanical parameters of bone in rat. Methods: 34 male wistar rats were divided into five groups: Control diet, Fluoride, Fluoride+Boron, Fluoride+ Ca+D, and Fluoride+B+Ca+D. Boron equal to 1.23 mg, Ca and Vit D 210 mg-55 IU and F, 0.7 mg/rat/day was added to their drinking water for 8 weeks. The serum level of the above elements was analyzed. The change in mechanical properties of femur and fifth vertebral body were also tested. Results: The addition of F+B intake revealed significant effects on bone mechanical changes properties and bone metabolic hormones. These findings suggested that combined intake of the above two elements had beneficial effect on bone stinffness and breaking strenght compared with Ca+Vit D supplementation. Conclusion: Dealing with health problems related to the skeletal system in humans, this paper justifies further investigation into the role of Boron and Fluoride in bone mass and strength.
