Evaluation of the Effectiveness of a Kind of Nutritious Supplement on Pain and Joint Function in Patients with Knee Osteoarthritis

Shayesteh Azar, Masoud; Nazar, Eisa; Hoseinian, Mohamadmohsen; Fekri, Fateme

doi:10.22034/ijos.2025.545486.1149

Evaluation of the Effectiveness of a Kind of Nutritious Supplement on Pain and Joint Function in Patients with Knee Osteoarthritis

Document Type : Original Article

Authors

Masoud Shayesteh Azar ¹

Eisa Nazar ²

mohamadmohsen hoseinian ³

fateme fekri ⁴

¹ Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

² Orthopedic Research Center, Mazandaran University

³ orthopedic research center,Mazandaran university of medical science,,sari ,iran

⁴ مرکز تحقیقات ارتوپدی، دانشگاه علوم پزشکی مازندران، ساری، ایران.

10.22034/ijos.2025.545486.1149

Abstract

Abstract
Introduction: Osteoarthritis (OA) is a common joint problem that primarily affects the knee joint, leading to significant disability and imposing a substantial burden on healthcare systems. Therefore, treatment aimed at minimizing physical dysfunction in these patients is of great importance. This study aimed to assess how well a type of nutritional supplement works to reduce pain and improve joint function in people with knee osteoarthritis.
Materials & Methods: This study was a randomized, double-blind clinical trial conducted on patients who presented to the orthopedic clinics in one year. Patients in the intervention group received a kind of nutritious supplement along with standard therapy, but control group received standard therapy with a placebo. Statistical analyses were performed using SPSS version 20, with the significance level described 0.05.
Results & Discussion: The mean age was 58.93 ± 5.65 years in the control and 59.77 ± 6.44 years in intervention groups, and no statistically significant difference between them (P > 0.05). Results from multiple covariance regression analysis demonstrated a statistically significant difference between the two groups in terms of pain severity, symptom scores, functional capacity, and total WOMAC score (P < 0.05).
Conclusion: Daily administration of this nutritious supplement for up to two months, in addition to standard therapy, is recommended for patients with knee osteoarthritis. This regimen can result in clinically meaningful improvement in pain, symptom severity, functional capacity, and total WOMAC score.

Keywords

Food assistance, Osteoarthritis, Knee, Functional status, Pain

Subjects