A Comparative Study on the Efficacy of Hydroalcoholic Extract of R. damascena, ‎Dexamethasone, and Vitamin E in Promoting Healing of Acute Achilles Tendon Injuries ‎in Rats‎

Zare, Masoud; Nourbakhsh, Mostafa; Namjou, Abdolrasoul; Samsam Shariat, Farnaz Sadat; Moradi Kalamui, Reza

doi:10.22034/ijos.2024.404795.1063

A Comparative Study on the Efficacy of Hydroalcoholic Extract of R. damascena, ‎Dexamethasone, and Vitamin E in Promoting Healing of Acute Achilles Tendon Injuries ‎in Rats‎

Document Type : Original Article

Authors

Masoud Zare ¹

Mostafa Nourbakhsh ²

Abdolrasoul Namjou ³

farnaz sadat Samsam Shariat ¹

Reza Moradi kalamui ¹

¹ Faculty of Veterinary Medicine, Shahrekord, Islamic Azad University, Shahrekord, Iran

² Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord, Islamic Azad University, Shahrekord, Iran

³ Department of Veterinary Pathology, Faculty of Veterinary Medicine, Shahrekord, Islamic Azad University, Shahrekord, Iran

https://doi.org/10.22034/ijos.2024.404795.1063

Abstract

Purpose of Review: Tendinopathy, also called tendinitis, is a common issue in musculoskeletal consultations. Tendon healing is inferior to normal due to low metabolic rate and poor vascularity. R. damascena has anti-inflammatory, antioxidant, and healing effects. This study aims to investigate R. damascene's effects on Achilles tendon injury using histopathology and biomechanical evaluations.

Materials/Methods: Wistar rats were divided into seven groups, including a control group and three groups with tendinitis, that were given different doses of Hydroalcoholic Extract of R. damascene (HERD) (250, 500, 1000 mg/kg) intraperitoneally. Dexamethasone and Vitamin E were used in the reference groups. The Achilles tendon was injured, and the extract was administered for 20 days. Histopathological assessment and antioxidant activity were determined by serum malondialdehyde levels and ferric-reducing antioxidant power assays on days 10 and 20.

Results: Different dosages of HERD, particularly 1000 mg, improved inflammatory intensity, angiogenesis, fibroplasia, and complete tendon regeneration on the 10th and 20th days after the injury, while also reducing unsaturated fatty acid peroxidation and increasing the whole serum's antioxidant capacity on the 20th day.

Conclusions: After a thorough review, it can be concluded that HERD is an effective anti-inflammatory agent and analgesic for preventing and treating tendinitis. Furthermore, it has been deemed safe and well-tolerated, making it a promising option for those seeking relief from the symptoms of tendinitis.

Keywords

Tendon Injuries

repair

Rosa damascene

dexamethasone

vitamin E

Subjects