Iranian Journal of Orthopedic Surgery

Prevalence of Deep Vein Thrombosis Following Knee Replacement Surgery in Patients with a History of Chemotherapy

Document Type : Original Article

Authors

Alireza Naseri
Abbasali Dehghani 1
Mohammad Reza Moharrami 2

1 Assistant Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 Assistant Professor of Orthopaedics, Department of Orthopedics, School of Medicine, Shohada Medical Research & Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

https://doi.org/10.22034/ijos.2021.130300
Abstract
Introduction: Deep vein thrombosis (DVT) is accompanied by adverse effects after surgery and the prevalence of this complication is unknown following knee replacement surgery in patients with a history of chemotherapy. Therefore, the present study aimed to investigate the frequency of DVT after knee replacement surgery in patients with a history of chemotherapy.
Methods: This descriptive-analytical study was performed on 189 candidates for knee replacement surgery who had a history of chemotherapy during 36 months ending in March 2016 and referred to Shohada and Imam Reza hospitals affiliated to Tabriz University of Medical Sciences, Tabriz, Iran. After surgery, patients were evaluated for the incidence of DVT and the factors, influecing it based on the instrument of determining DVT and Doppler ultrasound. Statistical analysis was completed by Spearman’s correlation and regression tests.
Results: The mean standard deviation of DVT score was 43.49 ± 6.66, which indicates that after knee replacement surgery, patients with a history of chemotherapy are at high risk for DVT. The prevalence of DVT was 25.92% (N=49) and the number of chemotherapy sessions (P=0.001) correlated with the occurrence of DVT.
Conclusion: The prevalence of DVT following knee replacement surgery in people with a history of chemotherapy is above the normal mean reported in the literature. Consequently, further therapeutic and preventive measures are required.

Keywords

Deep vein thrombosis
Knee replacement Arthroplasty
Chemotherapy
Risk factors
knee

Subjects

  1. Jiang T, Song K, Yao Y, Pan P, Jiang Q. Perioperative allogenic blood transfusion increases the incidence of postoperative deep vein thrombosis in total knee and hip arthroplasty. Journal of orthopaedic surgery and research. 2019;14(1):1-6.
  2. Alvandfar D, Alizadeh M, Khanbabayi Gol M. Prevalence of pregnancy varicose and its effective factors in women referred to gynecology hospitals in Tabriz. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2019;22(9):1-7.
  3. Liu P, Liu J, Chen L, Xia K, Wu X. Intermittent pneumatic compression devices combined with anticoagulants for prevention of symptomatic deep vein thrombosis after total knee arthroplasty: a pilot study. Therapeutics and clinical risk management. 2017;13:179.
  4. Zan P, Mol M, Yao J, Fan L, Yang D, Liu K, et al. Release of the tourniquet immediately after the implantation of the components reduces the incidence of deep vein thrombosis after primary total knee arthroplasty. Bone & joint research. 2017;6(9):535-41.
  5. Bawa H, Weick JW, Dirschl DR, Luu HH. Trends in deep vein thrombosis prophylaxis and deep vein thrombosis rates after total hip and knee arthroplasty. JAAOS-Journal of the American Academy of Orthopaedic Surgeons. 2018;26(19):698-705.
  6. Tateiwa T, Ishida T, Masaoka T, Shishido T, Takahashi Y, Onozuka A, et al. Clinical course of asymptomatic deep vein thrombosis after total knee arthroplasty in Japanese patients. Journal of Orthopaedic Surgery. 2019;27(2):2309499019848095.
  7. Wang K, Sun W, Shi X. Upper extremity deep vein thrombosis after migration of peripherally inserted central catheter (PICC): A case report. Medicine. 2017;96(51).
  8. Alvandfar D, Mohammadipour Anvari H, Nazari M. Frequency of deep vein thrombosis in women over 40 years old with breast cancer undergoing chemotherapy referred to Tabriz chemotherapy clinics in 2018. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2020;22(11):8-14.
  9. Chang MJ, Song MK, Kyung MG, Shin JH, Chang CB, Kang S-B. Incidence of deep vein thrombosis before and after total knee arthroplasty without pharmacologic prophylaxis: a 128-row multidetector CT indirect venography study. BMC musculoskeletal disorders. 2018;19(1):1-6.
  10. Snyder MA, Sympson AN, Scheuerman CM, Gregg JL, Hussain LR. Efficacy in deep vein thrombosis prevention with extended mechanical compression device therapy and prophylactic aspirin following total knee arthroplasty: a randomized control trial. The Journal of arthroplasty. 2017;32(5):1478-82.
  11. Yao Y, Qiao L, Song K, Xu X, Shi D, Xu Z, et al. Preoperative evaluation of soleal vein diameter by ultrasound is beneficial for prophylaxis of deep vein thrombosis after total knee or hip arthroplasty. BioMed research international. 2018;2018.
  12. Zhang Z, Song K, Yao Y, Jiang T, Pan P, Jiang Q. Incidence and risk factors for post-thrombotic syndrome in patients with deep vein thrombosis following total knee and hip arthroplasty. The Journal of arthroplasty. 2019;34(3):560-3.
  13. Wakabayashi H, Hasegawa M, Niimi R, Yamaguchi T, Naito Y, Sudo A. The risk factor of preoperative deep vein thrombosis in patients undergoing total knee arthroplasty. Journal of Orthopaedic Science. 2017;22(4):698-702.

14. Cafri G, Paxton EW, Chen Y, Cheetham CT, Gould MK, Sluggett J, et al. Comparative effectiveness and safety of drug prophylaxis for prevention of venous thromboembolism after total knee arthroplasty. The Journal of arthroplasty. 2017;32(11):3524-8. e1.

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