Effects of concurrent using of Theranekron with hydroxyapatite on bone healing in rabbit model: Radiological and histopathological evaluation

Bigham-Sadegh, Amin; Karimi, Iraj; Hoseini, Farzaneh; Moradi, Hamid

doi:10.22034/ijos.2020.121335

Effects of concurrent using of Theranekron with hydroxyapatite on bone healing in rabbit model: Radiological and histopathological evaluation

Authors

Amin Bigham-Sadegh

Iraj Karimi

Farzaneh Hoseini

Hamid Moradi

https://doi.org/10.22034/ijos.2020.121335

Abstract

Background: Nowadays, bone grafting is used in both human and veterinary orthopedics to stimulate fracture healing, accelerate joint ::::union::::, and to restore bone defects. In such procedures, orthopedic surgeons are searching to favorable substitute for autograft bone. The purpose of this study is evaluation of theranekron and hydroxyapatite effects on bone healing in rabbit model.
Methods: First, 20 rabbits were prepared and they were divided into four groups of five. In the group of theranecron, theranecrone was injected to the bone defected site on days 3, 7, and 10 after surgery and one of the group was left empty as control group and in the third group combination of the theranekron and hydroxyapatite was filled in the defected site and in the final group hydroxyapatite was implanted alone. Radiographs from rabbit's hand after surgery were taken on days 14, 28, 42, 56 in lateral view. At the end of the study, histopathological samples were taken from injured area of radius.
Results: In radiographical and histopathological evaluations the group of theranekron-hydroxyapatite had the best performance in healing criteria and the control group was the weakest group.
Conclusion: theranekron group and theranekron –hydroxyapatite groups were better than two other groups in bone healing criteria by radiological and histopathological evaluation.

Keywords

Bone healing

theranekron

Hydroxyapatite

Rabbit

radius