Comparing the Effect of Intraarticular Methylpredinsolone with Sodium Hyaluronate in the Treatment of Mild to Moderate Knee Joint Osteoarthritis

Fakoor, MD, Sajad; Farhadi, MD, Afshin; Fakoor, MD, Mohammad

doi:10.22034/ijos.2020.121279

Comparing the Effect of Intraarticular Methylpredinsolone with Sodium Hyaluronate in the Treatment of Mild to Moderate Knee Joint Osteoarthritis

Authors

Sajad Fakoor, MD

Afshin Farhadi, MD

Mohammad Fakoor, MD

https://doi.org/10.22034/ijos.2020.121279

Abstract

Background: Knee osteoarthritis is a common joint disorder in the older age patients. This study was performed to compare the efficacy of injection of methyl-prednisolone versus sodium-hyaluronate in symptomatic mild to moderate knee osteoarthritis.Methods: In a randomized clinical trial, 53 patients with knee osteoarthritis were assigned to receive either methyl-prednisolone (26 patients) or sodium-hyaluronate (27 patients) in a hospital in Tehran, Iran. Sodium-hyaluronate three injections within 2-weeks interval and a single injection of 40 mg of methyl-prednisolone were given. The improvement rate was compared after one and six months.Results: The total score significantly improved in both groups (p < /em>=.001). There was no significant difference between the two groups after the first month (p < /em>≥.05) but the results were better after six months in sodium-hyaluronate injection group (p < /em>=.001).Conclusions: Intra-articular injection of sodium-hyaluronate in comparison with methyl-prednisolone has longer efficacy in treatment of symptoms of mild to moderate knee osteoarthritis.

Keywords

osteoarthritis

knee

Intraarticular injection

treatment