Iranian Journal of Orthopedic Surgery

Effect of Intra-Articular Hyaluronic Acid or Methyl Prednisolone, or Oral Anti-Inflammatory Drugs in Knee Osteoarthritis (A Comparative Study)

Authors

Ali Akbar Esmaieliejah, MD
Mohammad Reza Abbassian, MD
Hamid Reza Hosseinzadeh, MD
Seyed Mohammad Jazayeri, MD
Mehrnoosh Hasas Yeganeh, MD
Nima Mohsseni, MD
https://doi.org/10.22034/ijos.2020.121196
Abstract
Background: Osteoarthritis is a relatively common ailment of human beings. The aim of this study is to compare the short-term effects of oral non-steroid anti-inflammatory medications with intra-articular injections of Hyaluronic Acid or Methyl Prednisolone acetate.Methods: In a clinical trial study, 40 female patients with moderate or severe knee osteoarthritis received Hyaluronic Acid intra-articular injections. They were compared with 16 cases who had intra-articular Prednisolone injection and 36 female patients who received non-steroid anti-inflammatory oral medication. The results were evaluated in 6 and 24 weeks by Visual Analogue Scale and Western Ontario & McMaster Universities (WOMAC) functional score.Results: Pain relief in 6 and 24 weeks post injection were 4.9 and 4.7 for Hyaluronic Acid, and 1.5 and 1.6 for Prednisolone. The figures for oral non-steroidal anti-inflammatory medication were 5.2 and 4.9 respectively. Subjective patient’s satisfaction was expressed in 28 (70%) of Hyaluronic Acid group and 16 (100%) of Prednisolone group.Conclusions: After 6 and 24 weeks following intra-articular steroid injection in female patients with knee osteoarthritis, pain relief and subjective patient satisfaction is more favorable compared to intra-articular Hyaluronic Acid injection. These two are both more effective than oral anti-inflammatories. This statement does not include the potential side-effects of intra-articular steroid injection in long-term.

Keywords

osteoarthritis
knee
Injections
Intra-Articular
Hyaluronic acid

Home

Submit Manuscript

Contact Us