Iranian Journal of Orthopedic Surgery

The Effect of Supplementation of Ca, Vit D, Boron and Increased Flouride Intake on Mechanical Properties of Bone and Metabolic Hormones in Rat

Authors

Ghader Ghanizadeh
Mohammad Reza Naghii
Giti Torkaman
Mohamood Mofid
Mehdi Hedayati
Peyman Darwishi
Yousef Ebrahimpoor
https://doi.org/10.22034/ijos.2020.121037
Abstract
Background: Optimal nutrition plays a role in formation and maintenance of bone. Besides major components of mineralization such as Ca, P and Vitamin D, other nutrients like Boron and Fluoride have also beneficial role. In this study, we are reporting the effect of these elements on metabolic hormones and biomechanical parameters of bone in rat. Methods: 34 male wistar rats were divided into five groups: Control diet, Fluoride, Fluoride+Boron, Fluoride+ Ca+D, and Fluoride+B+Ca+D. Boron equal to 1.23 mg, Ca and Vit D 210 mg-55 IU and F, 0.7 mg/rat/day was added to their drinking water for 8 weeks. The serum level of the above elements was analyzed. The change in mechanical properties of femur and fifth vertebral body were also tested. Results: The addition of F+B intake revealed significant effects on bone mechanical changes properties and bone metabolic hormones. These findings suggested that combined intake of the above two elements had beneficial effect on bone stinffness and breaking strenght compared with Ca+Vit D supplementation. Conclusion: Dealing with health problems related to the skeletal system in humans, this paper justifies further investigation into the role of Boron and Fluoride in bone mass and strength.

Keywords

Boron
Calcium
Floride
Vitamin D
Bone and Bones

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