Effects of Cox2-Inhibitors on the Rehabilitation of the Arthroscopic Reconstruction of the Anterior Cruciate Ligament

Farahanchi Baradaran, Mohammad Reza; Kazemi, Seyyed Morteza; Hosseini Khameneh, Seyyed Mehdi; Jazaeri, Seyyed Mohammad; Madadi, Firooz; Ashoori, Keyghobad; Kazemi, Katayoon; Zandi, Reza; Safdari, Farshad

doi:10.22034/ijos.2020.121024

Effects of Cox2-Inhibitors on the Rehabilitation of the Arthroscopic Reconstruction of the Anterior Cruciate Ligament

Authors

Mohammad Reza Farahanchi Baradaran

Seyyed Morteza Kazemi

Seyyed Mehdi Hosseini Khameneh

Seyyed Mohammad Jazaeri

Firooz Madadi

Keyghobad Ashoori

Katayoon Kazemi

Reza Zandi

Farshad Safdari

https://doi.org/10.22034/ijos.2020.121024

Abstract

Background: Arthroscopic reconstruction of the anterior cruciate ligament is one the most common orthopaedic surgeries. There are scattered reports about the beneficial effects of post operative cox2-inhibitors administration on knee motion. The purpose of the current study was to determine the effects of cox-2 inhibitor on pain, range of motion and weight bearing after arthroscopic reconstruction of the anterior cruciate ligament. Methods: In this clinical trial, 70 patients who underwent arthroscopic reconstruction of the anterior cruciate ligament were assessed in a teaching hospital in Tehran-Iran. They were divided into case (cox2-inhibitor) and control groups. Postoperatively, pain, inflammation, range of motion and ability for full weight bearing were measured. Results: The mean of pain at the postoperative day 3 was 5.3±1.04 (visual analogs scale of 0 to 10) in the control and 3.3±0.71 in the case group. 29.6% of the patients in the control group and 82.8% in the case group were able to flex the knee more than 90° one week postoperatively. In the first week, all of the patients in the case group and only 28.6% in the control group were able to walk without any assistive device. The post operative knee circumstances were 2.73±0.59 and l.61±0.92 centimeters smaller respectively in case and control groups. Statistical analysis showed significant differences between the two groups, in the above measurements. Conclusion: Cox-2 inhibitor is effective in relieving pain reducing the inflammation, and accelerating the rehabilitation program after arthroscopic reconstruction of the anterior cruciate ligament.

Keywords

Cyclooxygenase 2 Inhibitors

Rehabilitation

Anterior cruciate ligament