Stimulation and Acceleration of Bone Regeneration and Fracture Repair by Biomaterials with Immunomodulatory Properties (A review paper)
Volume 19, Issue 4, Autumn 2021, Pages 176-184
https://doi.org/10.22034/ijos.2021.141944
Vahid Zarghami, Fereshteh Moharramzadeh Jeghanab, Mohammad Ali Shokrgozar
Abstract Background: One of the issues related to stimulating and accelerating bone regeneration and bone repair is the role of the immune system in fracture healing, known as osteo-immunology.
Method: In these review 57 articles of science direct and pumped database is investigated for potential role and mechanism of the immune system's response to bone fracture.
Results: biological materials such as tumor necrosis factor alpha (TNF-α), lipopolysaccharide (LPS), interleukin-17 (IL-17) protein, lipotic Acid (LTA) could regulate the immune system, which have the ability to improve the ossification process and faster healing.
Conclusion: The direction of future research was predicted regarding the emergence of new therapeutic compounds derived from bone-building materials such as bone growth factors and substances that regulate the behaviour of the immune system in order to regenerate bone.