Comparing the Effect of Intraarticular Methylpredinsolone with Sodium Hyaluronate in the Treatment of Mild to Moderate Knee Joint Osteoarthritis
Volume 12, Issue 4, Autumn 2014, Pages 160-167
https://doi.org/10.22034/ijos.2020.121279
Sajad Fakoor, MD, Afshin Farhadi, MD, Mohammad Fakoor, MD
Abstract Background: Knee osteoarthritis is a common joint disorder in the older age patients. This study was performed to compare the efficacy of injection of methyl-prednisolone versus sodium-hyaluronate in symptomatic mild to moderate knee osteoarthritis.Methods: In a randomized clinical trial, 53 patients with knee osteoarthritis were assigned to receive either methyl-prednisolone (26 patients) or sodium-hyaluronate (27 patients) in a hospital in Tehran, Iran. Sodium-hyaluronate three injections within 2-weeks interval and a single injection of 40 mg of methyl-prednisolone were given. The improvement rate was compared after one and six months.Results: The total score significantly improved in both groups (p < /em>=.001). There was no significant difference between the two groups after the first month (p < /em>≥.05) but the results were better after six months in sodium-hyaluronate injection group (p < /em>=.001).Conclusions: Intra-articular injection of sodium-hyaluronate in comparison with methyl-prednisolone has longer efficacy in treatment of symptoms of mild to moderate knee osteoarthritis.