Iranian Journal of Orthopedic Surgery

Abstract Abstract
Introduction: Osteoporosis is currently a public health problem and is known as the silent disease of the century. The complications of osteoporosis affect people's lives and lead to anxiety and depression. The main purpose of our study is to determine the frequency of depressive symptoms and related factors in patients with osteoporosis.
Materials & Methods: The present study is an analytical cross-sectional study that was conducted on 35 patients with osteoporosis who referred to the osteoporosis clinic of a teaching hospital between March 2024 and March 2025. Patient information was gathered using a researcher-made checklist and the Hospital Anxiety and Depression (HADS) questionnaire. All statistical analyses were performed using SPSS 20 software at a significance level of 0.05.
Results & Discussion: Out of the 35 patients studied, 24(68.57%) exhibited depressive symptoms. Of these, 32(91.40%) were female, and 3(8.60%) were male. Depressive symptoms were observed in 65.60% of women and in all men. The overall mean age of the patients was 63.86±6.80 years. Among the patients, 7(46.70%) with diabetes and 17(85.00%) without diabetes had depressive symptoms, showing a statistically significant link between diabetes and depressive symptoms in osteoporosis patients (P<0.05). However, no statistically significant association was found between other variables and depressive symptoms in patients with osteoporosis (P>0.05).
Conclusion: The findings of the present study suggests that the frequency of depressive symptoms is high in patients with osteoporosis; therefore, it should be considered as an important factor in the treatment of osteoporosis.

Abstract Abstract
Introduction: Osteoarthritis (OA) is a common joint problem that primarily affects the knee joint, leading to significant disability and imposing a substantial burden on healthcare systems. Therefore, treatment aimed at minimizing physical dysfunction in these patients is of great importance. This study aimed to assess how well a type of nutritional supplement works to reduce pain and improve joint function in people with knee osteoarthritis.
Materials & Methods: This study was a randomized, double-blind clinical trial conducted on patients who presented to the orthopedic clinics in one year. Patients in the intervention group received a kind of nutritious supplement along with standard therapy, but control group received standard therapy with a placebo. Statistical analyses were performed using SPSS version 20, with the significance level described 0.05.
Results & Discussion: The mean age was 58.93 ± 5.65 years in the control and 59.77 ± 6.44 years in intervention groups, and no statistically significant difference between them (P > 0.05). Results from multiple covariance regression analysis demonstrated a statistically significant difference between the two groups in terms of pain severity, symptom scores, functional capacity, and total WOMAC score (P < 0.05).
Conclusion: Daily administration of this nutritious supplement for up to two months, in addition to standard therapy, is recommended for patients with knee osteoarthritis. This regimen can result in clinically meaningful improvement in pain, symptom severity, functional capacity, and total WOMAC score.