نوع مقاله : مروری

نویسندگان

1 بانک سلولی ایران، انستیتو پاستور ایران، تهران، ایران.

2 پژوهشکده علوم و فناوری نانو، دانشگا ه صنعتی شریف.

3 استاد تمام، بانک سلولی ایران، انستیتو پاستور ایران، تهران، ایران.

چکیده

مقدمه: یکی از مسائلی که در ارتباط با تحریک و تسریع بازسازی استخوان و ترمیم شکستگی های استخوانی وجود دارد استفاده و تنظیم عملکرد
سیستم ایمنی بدن در راستای استخوان سازی سریع و بهبود عیوب است که تحت عنوان استئوایمونولوژی شناخته میشود.
مواد و روشها: در این مقاله مروری، با بررسی 57 مقاله از منابع ScienceDirect و PubMed روش مواجهه ی سیستم ایمنی بدن هنگام بروز
شکستگی های استخوانی بررسی شده است.
نتایج: مواد بیولوژیکی از قبیل فاکتور نکروز توموری آلفا (TNF-α)، لیپوپلی ساکارید (LPS)، پروتئین اینترلوکین 17 (IL-17)، لیپوتیکوئیک اسید
(LTA) به عنوان مواد دارای خاصیت تنظیم کننده ی سیستم ایمنی معرفی شدند که دارای قابلیت بهبود فرآیند استخوان سازی و ترمیم سریع تر از
طریق تحریک سیستم هستند.
نتیجه گیری: جهت گیری پژوهش های آینده، در خصوص پیدایش ترکیبات درمانی جدید حاصل از مواد استخوان ساز از قبیل فاکتورهای رشد
استخوانی و مواد تنظیم کننده ی رفتار سیستم ایمنی بدن در راستای بازسازی استخوان پیش بینی شد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Stimulation and Acceleration of Bone Regeneration and Fracture Repair by Biomaterials with Immunomodulatory Properties (A review paper)

نویسندگان [English]

  • Vahid Zarghami 1
  • Fereshteh Moharramzadeh Jeghanab 2
  • Mohammad Ali Shokrgozar 3

1 National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

2 Institute for Nanoscience & Nanotechnology, Sharif University of Technology Tehran, Iran.

3 Professor, National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.

چکیده [English]

Background: One of the issues related to stimulating and accelerating bone regeneration and bone repair is the role of the immune system in fracture healing, known as osteo-immunology.
Method: In these review 57 articles of science direct and pumped database is investigated for potential role and mechanism of the immune system's response to bone fracture.
 Results: biological materials such as tumor necrosis factor alpha (TNF-α), lipopolysaccharide (LPS), interleukin-17 (IL-17) protein, lipotic Acid (LTA) could regulate the immune system, which have the ability to improve the ossification process and faster healing.
Conclusion: The direction of future research was predicted regarding the emergence of new therapeutic compounds derived from bone-building materials such as bone growth factors and substances that regulate the behaviour of the immune system in order to regenerate bone.

کلیدواژه‌ها [English]

  • Biocompatible materials
  • Bone regeneration
  • Immunomodulation
  • Osteogenesis
 
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